Seroconversion of a Thermostable live Attenuated Lentogenic Strain Newcastle Disease Vaccine (Local isolate) in Chicken

Efficacy of thermostable I-2 Newcastle disease vaccine compared to B1 commercial vaccine in broiler chicken

Frequent vaccination failures have occurred in the broiler farms in Eurasian countries during Newcastle disease outbreaks. The disease is enzootic in many countries of the region, especially in southwest Asia. I-2 vaccine has been used successfully in village chickens in many Asian and African countries. Our preliminary study showed good efficacy of the vaccine in broiler chickens. Therefore th...

Induction of Intestinal Immune Response to Lentogenic Vaccine Strain of Newcastle Disease Virus in Chicken

Mucosal surface provide portal entry for a majority of infectious agents. Hence, protection at the mucosal surface through immunization plays an important role in containing its systemic spread. Mucosal vaccination of chicken at early stages of life with live attenuated strain of Newcastle disease virus (NDV) induces both cellular and humoral immune responses against the Newcastle disease. In o...

Experimental study of a further attenuated live measles vaccine of the Sugiyama strain in Iran

Caution about Newcastle disease virus-based live attenuated vaccine.

In several recent papers, two published last year in the Journal of Virology by DiNapoli et al. (3) and Ge et al. (4), an earlier study by Martinez-Sobrido et al. in 2006 (6), and a review by Bukreyev et al. in 2006 (1), Newcastle disease virus (NDV) is proposed as a potential vector in the development of a novel bior multivalent vaccine. We question whether those studies satisfactorily address...

Nucleotide mutation analyses of isolated lentogenic newcastle disease virus in live bird market

Newcastle Disease (ND) is a major viral disease in Indonesia. It is an RNA virus belongs to Paramyxovirinae. It is well known that RNA virus is easily to mutate. In some cases, this mutation could generate virulence alteration. It is noted that mutation of NDV which has avirulent amino acid sequence on the cleavage site, could mutate to be virulent Newcastle Disease Virus (NDV). It is needed to...